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A Review on Synthesis, Characterization, and Pharmacological Properties of Some Sydnone Derivatives
Mini-Reviews in Organic Chemistry ( IF 2.3 ) Pub Date : 2023-09-01 , DOI: 10.2174/1570193x21666230831153810
Takallum Khan 1 , Ritu Yadav 2 , Amul Kumar Kesharwani 2 , Karuna Chourasia 2
Affiliation  

: The mesoionic compounds have great importance due to their dipolar nature. They are versatile synthons in synthetic chemistry and possess various chemotherapeutic activities. The most important moiety found in mesoionic compounds is the sydnone ring system. Sydnone derivatives have stimulated much interest among synthetic researchers as a result of their unique dipolar, mesoionic character. This ring system is also associated with a wide variety of biological activities. Sydnone derivatives have various applications in synthetic and medicinal chemistry. Sydnones are very useful precursors for selective heterocycles (pyrazoles, imidazoles, oxadiazoles, oxazoles, thiazoles, and tetrazoles), which has also served to initiate research into their functionalization and cycloaddition chemistry, paving the way for stimulated extensive research on the use of sydnones in chemical and industrial applications. So, this review article offers a wide scope of synthesis and applications of sydnone derivatives.

中文翻译:

部分苯乙烯酮衍生物的合成、表征及药理性质研究进展

:介离子化合物由于其偶极性质而具有非常重要的意义。它们是合成化学中的多功能合成子,并具有多种化疗活性。介离子化合物中发现的最重要的部分是苯乙烯酮环系统。苯乙烯酮衍生物因其独特的偶极、介离子特性而引起了合成研究人员的极大兴趣。该环系统还与多种生物活性相关。苯乙烯酮衍生物在合成化学和药物化学中具有多种应用。苯乙烯酮是选择性杂环(吡唑、咪唑、恶二唑、恶唑、噻唑和四唑)非常有用的前体,这也有助于启动对其官能化和环加成化学的研究,为刺激在化学和工业应用中使用悉尼酮的广泛研究铺平了道路。因此,这篇综述文章提供了悉尼酮衍生物的广泛合成和应用。
更新日期:2023-09-01
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