Abstract

Low vitamin D levels and adverse effects have been reported in SARS-COV-2 positive patients. This study examined the effect of the vitamin D receptor gene BsmI polymorphism on SARS-COV-2 positive patients. A total of 80 SARS-COV-2 positive inpatients were included in the study, and 110 healthy individuals were included as a control group. The 25-(OH) vitamin D3, lymphocyte, and activated partial thromboplastin time levels of SARS-COV-2 positive patients were lower than those of the control group. The prothrombin time (PT), international normalized ratio (INR), D-dimer, C-reactive protein (CRP), procalcitonin, and ferritin levels of SARS-COV-2 positive patients were higher than those of the control group. A negative correlation was found between 25-(OH) vitamin D3 levels and white blood cell count, PT, INR, D-dimer, CRP, procalcitonin, and ferritin levels in SARS-COV-2 positive patients. The 25-(OH) vitamin D3 level in individuals with the BB genotype was higher than the 25-(OH) vitamin D3 level in individuals with the Bb and bb genotype. A statistically significant difference was found between the groups in terms of the genotype and allele distributions of BsmI polymorphism. When the genotypes were analyzed in terms of bb versus Bb + BB, a statistically significant difference was found between the groups. However, this finding was not found between the intensive care inpatient subgroup and the other inpatient subgroup. In conclusion, BsmI b allele and bb genotype were associated with hospitalization for SARS-COV-2 infection. This may be because individuals with b allele have low levels of vitamin D.

摘要

据报道，SARS-COV-2 阳性患者的维生素 D 水平较低且存在不良反应。本研究探讨了维生素 D 受体基因 BsmI 多态性对 SARS-COV-2 阳性患者的影响。该研究共纳入80名SARS-COV-2阳性住院患者，并纳入110名健康个体作为对照组。SARS-COV-2阳性患者的25-(OH)维生素D3、淋巴细胞和活化部分凝血活酶时间水平低于对照组。SARS-COV-2阳性患者的凝血酶原时间（PT）、国际标准化比值（INR）、D-二聚体、C反应蛋白（CRP）、降钙素原和铁蛋白水平高于对照组。SARS-COV-2阳性患者的25-(OH)维生素D3水平与白细胞计数、PT、INR、D-二聚体、CRP、降钙素原和铁蛋白水平呈负相关。BB 基因型个体的 25-(OH) 维生素 D3 水平高于 Bb 和 bb 基因型个体的 25-(OH) 维生素 D3 水平。BsmI多态性的基因型和等位基因分布在各组之间存在统计学上的显着差异。当根据 bb 与 Bb + BB 分析基因型时，发现组间存在统计学显着差异。然而，在重症监护住院患者亚组和其他住院患者亚组之间并未发现这一发现。总之，BsmI b 等位基因和 bb 基因型与 SARS-COV-2 感染住院相关。这可能是因为带有 b 等位基因的个体维生素 D 水平较低。