Can human peripheral blood cells be used as a surrogate for bone marrow cells, in evaluating the genotoxic effects of stressors? We searched the Pubmed/Medline and PubChem databases to identify publications relevant to this question. Micronucleus formation was the genotoxicity endpoint. Three publications comparing exposed vs. non-exposed individuals are included in this analysis; the exposures were to ethylene oxide or ionising radiation (atomic bomb, thorotrast, or radioiodine therapy). Information was extracted on the types of exposure, the numbers of participants, and the micronucleus frequencies. Relative differences (odds ratios) and absolute differences (risk differences) in the numbers of micronuclei between exposed and non-exposed persons were calculated separately for individual cell types (peripheral blood and bone marrow). Random effects meta-analyses for the relative differences in cell abnormalities were performed. The results showed very small differences in the frequencies of micronuclei between exposed and non-exposed individuals, as measured in either peripheral blood or bone marrow cell populations, on both absolute and relative scales. No definite conclusion concerning the relative sensitivities of bone marrow and peripheral blood cells can be made, based on these publications.

人外周血细胞可以用作骨髓细胞的替代品来评估应激源的基因毒性效应吗？我们检索了 Pubmed/Medline 和 PubChem 数据库，以确定与此问题相关的出版物。微核形成是遗传毒性终点。该分析中包含了三篇比较暴露个体与非暴露个体的出版物；暴露于环氧乙烷或电离辐射（原子弹、胸透疗法或放射性碘疗法）。提取了有关暴露类型、参与者数量和微核频率的信息。分别计算个体细胞类型（外周血和骨髓）的暴露者和非暴露者之间微核数量的相对差异（比值比）和绝对差异（风险差异）。对细胞异常的相对差异进行随机效应荟萃分析。结果显示，在外周血或骨髓细胞群中测量，在绝对和相对尺度上，暴露和未暴露个体之间的微核频率差异非常小。根据这些出版物，无法得出关于骨髓和外周血细胞的相对敏感性的明确结论。