Abstract

Five coordination compounds [Cu₂(Bipy)₂L₄]·C₂H₅OH (Iа, Ib), [Cu₂(Dmbipy)₂L₄] (II), [Cu₂(Phen)₂L₄]·H₂O (IIIa), [Cu₂(Dmphen)₂L₄] (IVa), and [Cu₂(Phendione’)₂L₄]·2C₂H₅OH·2H₂O (V) are synthesized from 5-(4-chlorophenyl)-1H-tetrazole (HL), where Bipy is 2,2'-bipyridine, Dmbipy is 4,4'-dimethyl-2,2'-bipyridine, Phen is 1,10-phenanthroline, Dmphen is 4,7-dimethyl-1,10-phenanthroline, and Phendione’ is 6-ethoxy-6-hydroxy-1,10-phenanthrolin-5-one. The crystal structures of the complexes are determined by X-ray diffraction (XRD) of single crystals (CIF files CCDC nos. 2225368 (Ia), 2225369 (Ib), 2225370 (II), 2225372 (IIIa), 2225373 (IVa), and 2225371 (V)). The compounds are binuclear due to the bridging function of the tetrazolate anion, and the coordination number of copper is five in all synthesized complexes. The cytotoxic activity of the complexes against the Hep2 and HepG2 cancer cell lines and non-cancerous human fibroblasts MRC-5 is studied. The complexes exhibit pronounced cytotoxic properties, and compound V has the maximum selectivity index with respect to the cancer cells.

中文翻译：

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基于 2,2'-联吡啶/1,10-菲咯啉和 5-(4-氯苯基)-1H-四唑的细胞毒性铜 (II) 配合物：合成和结构

摘要

五种配位化合物[Cu ₂ (Bipy) ₂ L ₄ ]·C ₂ H ₅ OH ( Iа , Ib )、[Cu ₂ (Dmbipy) ₂ L ₄ ] ( II )、[Cu ₂ (Phen) ₂ L ₄ ]· H ₂ O ( IIIa )、[Cu ₂ (Dmphen) ₂ L ₄ ] ( IVa )、[Cu ₂ (Phendione') ₂ L ₄ ]·2C ₂ H ₅ OH·2H ₂O ( V ) 由 5-(4-氯苯基)-1 H -四唑 (HL) 合成，其中 Bipy 为 2,2'-联吡啶，Dmbipy 为 4,4'-二甲基-2,2'-联吡啶，Phen是1，10-菲咯啉，Dmphen是4，7-二甲基-1，10-菲咯啉，并且Phendione'是6-乙氧基-6-羟基-1，10-菲咯啉-5-酮。配合物的晶体结构通过单晶的 X 射线衍射 (XRD) 确定（CIF 文件 CCDC 编号 2225368 ( Ia )、2225369 ( Ib )、2225370 ( II )、2225372 ( IIIa )、2225373 ( IVa )、和2225371（V））。由于四唑阴离子的桥联作用，该化合物是双核的，并且所有合成的配合物中铜的配位数均为5。研究了复合物针对 Hep2 和 HepG2 癌细胞系以及非癌性人成纤维细胞 MRC-5 的细胞毒活性。该复合物表现出明显的细胞毒性特性，并且化合物V对癌细胞具有最大的选择性指数。