Abstract

New complexes CuCl₂[AbAc]₂ (I), CoCl₂[AbAc]₂ (II), and ZnCl₂[AbAc]₂ (III) with abiraterone acetate (AbAc) are synthesized. The molecular structure of complex II is determined by X-ray diffraction (XRD) (CIF file CCDC no. 2252346). The cobalt atom coordinates with abiraterone acetate due to the N‑donor pyridine atom. The model processes of hydrolysis of the compounds in acidic and neutral media and their ability to interact with the superoxide radical anion generated in the xanthine–xanthine oxidase enzymatic system are studied. A high activity of complexes I and II is found. The MTT test shows that the antiproliferative activity of compounds I–III against the HCT-116, MCF-7, A-549, and WI-38 cells is comparable with the activity of cisplatin and exceeds that of the initial AbAc for the PC-3 cell line. Complex II also induces cell cycle arrest in the G0/G1 phase of RNA protein synthesis.

中文翻译：

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醋酸阿比特龙新型铜、钴、锌配合物的合成及其抗增殖活性

摘要

合成了新的配合物 CuCl ₂ [AbAc] ₂ ( I )、CoCl ₂ [AbAc] ₂ ( II ) 和 ZnCl ₂ [AbAc] ₂ ( III ) 与醋酸阿比特龙 (AbAc) 的配合物。复合物II的分子结构通过 X 射线衍射 (XRD) 确定（CIF 文件 CCDC 编号 2252346）。由于 N-供体吡啶原子，钴原子与醋酸阿比特龙配位。研究了化合物在酸性和中性介质中水解的模型过程以及它们与黄嘌呤-黄嘌呤氧化酶酶系统中产生的超氧自由基阴离子相互作用的能力。配合物I的高活性并找到II 。MTT测试表明，化合物I - III对HCT-116、MCF-7、A-549和WI-38细胞的抗增殖活性与顺铂的活性相当，并且超过了PC-初始AbAc的活性。 3 细胞系。复合物II还诱导细胞周期停滞在 RNA 蛋白质合成的 G0/G1 期。