Abstract

The synthesis and data on the physicochemical characteristics and biological activity of the new iron nitrosyl complex (Q⁺)₂[Fe₂(S₂O₃)₂(NO)₄]^2– (I), where Q⁺ is protonated 2-ethyl-4-pyridinecarbothioamide (C₈H₁₁N₂S), are presented. The structure and properties of the complex were studied by X-ray diffraction, elemental analysis, IR and Mössbauer spectroscopy, and amperometry. The complex showed antibacterial activity and efficiently inhibited cyclic guanosine monophosphate phosphodiesterase (cGMP PDE), which may suggest its antihypertensive, anti-aggregation, and vasodilator activities.

中文翻译：

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2-乙基-4-吡啶硫代甲酰胺铁配合物的合成、结构和性能

摘要

新型亚硝酰铁配合物 (Q ⁺ ) ₂ [Fe ₂ (S ₂ O ₃ ) ₂ (NO) ₄ ] ^2– ( I ) 的合成及其理化特性和生物活性数据，其中 Q ⁺被质子化 2-乙基-4-吡啶硫代甲酰胺 (C ₈ H ₁₁ N ₂S），提出。通过 X 射线衍射、元素分析、红外和穆斯堡尔光谱以及电流分析法研究了配合物的结构和性质。该复合物表现出抗菌活性，并能有效抑制环鸟苷单磷酸磷酸二酯酶 (cGMP PDE)，这可能表明其具有抗高血压、抗聚集和血管扩张活性。