Background Mass drug administration (MDA) is among the five major strategies that are currently in use to control, eliminate or eradicate Neglected Tropical Diseases (NTDs). Optimising MDA to control multiple NTDs maximises impact. The objective of this study is to estimate the secondary impact of ivermectin MDA for onchocerciasis on the prevalence of scabies. Methods This quasi-experimental study was conducted in Ayu Guagusa district, northwestern Ethiopia. Scabies prevalence was estimated in surveys before the MDA, at 6 and 12 months afterwards. The sample size was 1437 people from a panel of 381 randomly selected study households. Multistage sampling was employed in randomly selecting six kebeles (the lowest administrative unit) with respective gotes (small villages) and households. All members of the selected households were invited to participate in the study and participants who were available in all three surveys formed a cohort. Results Scabies prevalence was similar prior to the MDA (13.4%, 95% CI 11.7 to 15.2%) and 6 months after (11.7%, 95% CI 10.1 to 13.2%) but was substantially greater at 12 months (22.1%, 95% CI 20.1 to 24.1%). The 6-month incidence and disappearance rates were 10.8% (95% CI 8.8 to 13.2%) and 82.6% (95% CI 75.0 to 88.6%), respectively. Conclusions Ivermectin MDA for onchocerciasis was not observed to have a secondary impact on the prevalence of scabies over the follow-up period of 12 months.

中文翻译：

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伊维菌素大规模给药消除盘尾丝虫病对埃塞俄比亚西北部疥疮患病率没有二次影响

背景 大规模药物管理（MDA）是目前用于控制、消除或根除被忽视的热带病（NTD）的五种主要策略之一。优化 MDA 来控制多种 NTD 可以最大限度地发挥影响。本研究的目的是评估伊维菌素 MDA 治疗盘尾丝虫病对疥疮患病率的二次影响。方法 这项准实验研究在埃塞俄比亚西北部的阿尤瓜古萨地区进行。在 MDA 之前、之后 6 个月和 12 个月的调查中估计了疥疮患病率。样本量为 1437 人，来自 381 个随机选择的研究家庭。采用多阶段抽样的方式，随机抽取6个kebeles（最低行政单位），分别设有gotes（小村庄）和住户。所选家庭的所有成员都被邀请参加这项研究，所有三项调查的参与者都组成了一个队列。结果 疥疮患病率在 MDA 之前（13.4%，95% CI 11.7 - 15.2%）和 6 个月后（11.7%，95% CI 10.1 - 13.2%）相似，但在 12 个月时明显更高（22.1%，95%） CI 20.1 至 24.1%）。6个月的发病率和消失率分别为10.8%（95% CI 8.8至13.2%）和82.6%（95% CI 75.0至88.6%）。结论 在 12 个月的随访期间，没有观察到伊维菌素 MDA 治疗盘尾丝虫病对疥疮患病率有二次影响。