BackgroundElectric field (E-field) modeling is a valuable method of elucidating the cortical target engagement from transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (tES), but it is typically dependent on individual MRI scans. In this study, we systematically tested whether E-field models in template MNI-152 and Ernie scans can reliably approximate group-level E-fields induced in N = 195 individuals across 5 diagnoses (healthy, alcohol use disorder, tobacco use disorder, anxiety, depression).MethodsWe computed 788 E-field models using the CHARM–SimNIBS 4.0.0 pipeline with 4 E-field models per participant (motor and prefrontal targets for TMS and tES). We additionally calculated permutation analyses to determine the point of stability of E-fields to assess whether the 152 brains represented in the MNI-152 template is sufficient.ResultsGroup-level E-fields did not significantly differ between the individual vs. MNI-152 template and Ernie scans for any stimulation modality or location (p > 0.05). However, TMS-induced E-field magnitudes significantly varied by diagnosis; individuals with generalized anxiety had significantly higher prefrontal and motor E-field magnitudes than healthy controls and those with alcohol use disorder and depression (p < 0.001). The point of stability for group-level E-field magnitudes ranged from 42 (motor tES) to 52 participants (prefrontal TMS).ConclusionMNI-152 and Ernie models reliably estimate group-average TMS and tES-induced E-fields transdiagnostically. The MNI-152 template includes sufficient scans to control for interindividual anatomical differences (i.e., above the point of stability). Taken together, using the MNI-152 and Ernie brains to approximate group-level E-fields is a valid and reliable approach.

中文翻译：

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模板 MRI 扫描可靠地近似运动和前额叶回路中感应的个体和群体水平 tES 和 TMS 电场

背景电场 (E-field) 建模是阐明经颅磁刺激 (TMS) 和经颅电刺激 (tES) 皮质目标参与的一种有价值的方法，但它通常依赖于单独的 MRI 扫描。在这项研究中，我们系统地测试了模板 MNI-152 和 Ernie 扫描中的电场模型是否能够可靠地近似在氮= 195 名受试者，涉及 5 种诊断（健康、酒精使用障碍、烟草使用障碍、焦虑、抑郁）。方法我们使用 CHARM–SimNIBS 4.0.0 流程计算了 788 个电场模型，每个参与者有 4 个电场模型（运动和前额叶） TMS 和 tES 的目标）。我们还计算了排列分析以确定电场的稳定点，以评估 MNI-152 模板中代表的 152 个大脑是否足够。结果个体与 MNI-152 模板之间的组级电场没有显着差异厄尼扫描任何刺激方式或位置（p> 0.05）。然而，TMS 引起的电场强度因诊断而异。患有广泛性焦虑症的人的前额叶和运动电场强度明显高于健康对照者以及患有酒精使用障碍和抑郁症的人。p< 0.001）。群体水平电场强度的稳定点范围为 42（运动 tES）到 52 名参与者（前额 TMS）。结论 MNI-152 和 Ernie 模型能够跨诊断可靠地估计群体平均 TMS 和 tES 诱发的电场。MNI-152 模板包括足够的扫描来控制个体间的解剖差异（即高于稳定点）。总而言之，使用 MNI-152 和 Ernie 大脑来近似群体级 E 场是一种有效且可靠的方法。