This MRI study examined the effects of birth seasons on gross brain characteristics, such as the prevalence/size of midline brain structures (cavum septi pellucidi and adhesio interthalamica), orbitofrontal surface morphology, and insular gross anatomy, in 135 patients with schizophrenia, 47 with schizotypal disorder, and 88 healthy controls. Birth seasons only affected the insular anatomy. Summer-born subjects (N = 110) were characterized by more developed left insular gyri than winter-born subjects; however, this effect had no diagnostic specificity. The present results do not support birth seasons affecting the neurodevelopmental pathology of schizophrenia spectrum.

这项 MRI 研究检查了出生季节对 135 名精神分裂症患者（其中 47 名患有精神分裂症）的大脑总体特征的影响，例如中线大脑结构（透明隔腔和丘脑间粘连）的患病率/大小、眶额表面形态和岛叶总体解剖结构。精神分裂症和 88 名健康对照。出生季节只影响岛的解剖结构。夏季出生的受试者（N  = 110）的特点是左岛回比冬季出生的受试者更发达；然而，这种效应没有诊断特异性。目前的结果并不支持出生季节影响精神分裂症谱系的神经发育病理学。