Aim

To examine the associations between serum albumin and the incidences of diabetes and diabetic microvascular complications in participants of the UK Biobank cohort.

Methods

There were 398,146 participants without diabetes and 30,952 patients with diabetes from the UK Biobank cohort included in this study. Multivariate-adjusted Cox proportional hazard models were used to analyze the association of albumin with the incidences of diabetes and diabetic microvascular complications. Mendelian randomization (MR) analysis was used to determine the genetic relationships between serum albumin and diabetes.

Results

After a median 12.90 years follow-up, 14,710 participants developed incident diabetes (58.83 ± 7.52 years, 56.10% male). After multivariate adjustment, serum albumin was inversely associated with incident diabetes: hazard ratio (HR) [95% confidence interval] per 10 g/l increase 0.88 [0.82;0.94]. MR analyses suggested a potential genetic influence of serum albumin on diabetes in both the UK Biobank and the FinnGen consortium: odds ratios (ORs) [95% confidence interval per 1 g/l increase 0.99 [0.98;1.00] and 0.78 [0.67;0.92], respectively. In patients with diabetes, higher serum albumin levels were significantly associated with lower risk for diabetic microvascular complications. Specifically, per 10 g/l increase in serum albumin, the HRs for diabetic nephropathy, ophthalmopathy, and neuropathy were 0.42 [0.30;0.58], 0.61 [0.52;0.72], and 0.67 [0.51;0.88], respectively.

Conclusion

In this large prospective study, serum levels of albumin were inversely associated with the incidences of diabetes and diabetic microvascular complications. These findings underscore the importance of maintaining optimal nutrient status in reducing the risk of diabetes and its complications.

中文翻译：

---

英国生物银行队列中的血清白蛋白与糖尿病和糖尿病微血管并发症的风险

目的

研究英国生物银行队列参与者的血清白蛋白与糖尿病和糖尿病微血管并发症发生率之间的关联。

方法

这项研究包括来自英国生物银行队列的 398,146 名非糖尿病参与者和 30,952 名糖尿病患者。使用多变量调整的Cox比例风险模型来分析白蛋白与糖尿病和糖尿病微血管并发症发生率的关联。孟德尔随机化（MR）分析用于确定血清白蛋白与糖尿病之间的遗传关系。

结果

经过中位 12.90 年的随访后，14,710 名参与者罹患糖尿病（58.83 ± 7.52 岁，56.10% 为男性）。多变量调整后，血清白蛋白与糖尿病发病呈负相关：风险比 (HR) [95% 置信区间] 每增加 10 g/l 0.88 [0.82;0.94]。MR 分析表明，英国生物银行和 FinnGen 联盟中血清白蛋白对糖尿病具有潜在的遗传影响：比值比 (OR) [95% 置信区间每增加 1 g/l 0.99 [0.98;1.00] 和 0.78 [0.67;0.92 ]， 分别。在糖尿病患者中，较高的血清白蛋白水平与较低的糖尿病微血管并发症风险显着相关。具体而言，血清白蛋白每增加 10 g/l，糖尿病肾病、眼病和神经病的 HR 分别为 0.42 [0.30;0.58]、0.61 [0.52;0.72] 和 0.67 [0.51;0.88]。

结论

在这项大型前瞻性研究中，血清白蛋白水平与糖尿病和糖尿病微血管并发症的发生率呈负相关。这些发现强调了维持最佳营养状态对于降低糖尿病及其并发症风险的重要性。