Dengue or breakbone fever is one of the most important causes of febrile illness in children residing in tropical and subtropical regions. This mosquito-borne viral disease is mediated by the bite of the infected Aedes mosquito. Dengue infection has been expanding rapidly throughout the globe in the past few decades. The virus has hepatotoxic effects. However, the pathophysiology of liver involvement in dengue is still not entirely clear. The reported clinical spectrum of dengue hepatitis ranges from mild asymptomatic elevation in transaminaselevels to acute liver failure in children. This review focuses on hepatic manifestation, the pathogenesis of liver injury, and treatment option of the effects of dengue on the liver in the pediatric population.

中文翻译：

---

儿童登革热感染涉及肝脏

登革热或断骨热是热带和亚热带地区儿童发热性疾病的最重要原因之一。这种蚊媒病毒性疾病是由受感染的伊蚊叮咬介导的。过去几十年来，登革热感染在全球范围内迅速蔓延。该病毒具有肝毒性作用。然而，登革热肝脏受累的病理生理学仍不完全清楚。据报道，登革热肝炎的临床范围从轻微的无症状转氨酶水平升高到儿童急性肝功能衰竭。本综述重点关注儿科人群的肝脏表现、肝损伤的发病机制以及登革热对肝脏影响的治疗选择。