The functionalization of the surface of silica-based nanoparticles with targeting ligands has demonstrated remarkable efficacy in enhancing their activity. In this study, the surface of mesoporous silica nanoparticles (MSN) was functionalized with the phosphonate group (-PO₃) to facilitate the adsorption and targeted delivery of curcumin to cancer cells, concurrently significantly enhancing the stability of the nanomaterial. Methodologies including scanning electron microscopy, Fourier transform infrared spectroscopy, N₂ adsorption isotherms, and thermal gravimetric analysis were systematically employed to characterize the features of the nanomaterials. The assessment of curcumin loading efficiency within both MSN and phosphonate-functionalized MSN (MSN-PO₃) was conducted, predicated upon interactions with the loading solvent and the material's stability. Notably, stability assays revealed that unmodified particles exhibited agglomeration within a 96-h period, while their modified counterparts maintained their structural integrity. Moreover, discerning outcomes from in vitro cytotoxicity assays unveiled the potent efficacy of curcumin-loaded materials against colorectal cancer cells (C-26), with minimal impact on fibroblast cells (L929). These collective results substantiate the role of these materials as efficacious nanocarriers for delivering anticancer drugs.

具有靶向配体的二氧化硅基纳米颗粒表面的功能化在增强其活性方面表现出显着的功效。在这项研究中，介孔二氧化硅纳米颗粒（MSN）的表面被膦酸酯基团（-PO ₃）功能化，以促进姜黄素吸附和靶向递送至癌细胞，同时显着增强纳米材料的稳定性。系统地采用扫描电子显微镜、傅里叶变换红外光谱、N ₂吸附等温线和热重分析等方法来表征纳米材料的特征。_{MSN 和膦酸酯功能化 MSN (MSN-PO 3} ) 中姜黄素负载效率的评估）的进行，基于与加载溶剂的相互作用和材料的稳定性。值得注意的是，稳定性测定表明，未修饰的颗粒在 96 小时内表现出团聚，而修饰后的颗粒则保持了结构完整性。此外，体外细胞毒性测定的显着结果揭示了姜黄素负载材料对结直肠癌细胞 (C-26) 的有效功效，而对成纤维细胞 (L929) 的影响最小。这些集体结果证实了这些材料作为传递抗癌药物的有效纳米载体的作用。