Three new amide derivatives (alteralkaloids A–C, 1–3) and three known alkaloids (4–6) were afforded after phytochemical investigation of fungus Alternaria brassicicola. The structures of these compounds were confirmed by NMR spectroscopic and HRESIMS data. Furthermore, the absolute configuration of 1 was determined using the single-crystal X-ray diffraction analysis. Compounds 1–3 belong to a class of amide derivatives that have not been found in nature before, sharing the same characteristic signals of the butyl moiety and amide group. These isolated compounds mentioned above were tested for the cytotoxic activity.

Graphical Abstract

中文翻译：

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来自真菌芸苔链格孢菌的三种新酰胺衍生物

对真菌Alternaria brasicicola进行植物化学研究后，得到了 三种新的酰胺衍生物（交替生物碱 A–C、1–3 ）和三种已知的生物碱（4–6 ） 。这些化合物的结构通过NMR波谱和HRESIMS数据得到证实。此外，使用单晶X射线衍射分析确定了1的绝对构型。化合物1-3属于以前在自然界中未发现的一类酰胺衍生物，具有相同的丁基部分和酰胺基团的特征信号。测试了上述这些分离的化合物的细胞毒活性。

图形概要