The main purpose of this study was the comparison of the results of quantification obtained via different sample preparation approaches such as microwave-assisted wet digestion (MAWD) and suspension preparation. Two total reflection x-ray fluorescence (TXRF) spectrometers equipped with Mo x-ray tubes were used to compare results obtained via two different paths of sample preparations which would further be compared to the conventional way of analysis by inductively coupled plasma optical emission spectrometry (ICP-OES) including MAWD. Three dietary supplement samples with different sets and concentrations of elements were analyzed. The benefits and limitations of the simplified path of sample preparation were highlighted. A round-robin test between TXRF and ICP-OES was discussed. Accuracy as the percentage of recovery in all measurements ranged from 80 to 120. Precision for all results did not exceed 8% for TXRF and 5% for ICP-OES. Limits of quantification by TXRF are ranged from 1 to 0.01 mg/pill for different elements. It was shown that suspension preparation of samples might be a useful response to increasing demand for quality control of dietary supplements since it is less time consuming and cost efficient.

中文翻译：

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通过全反射 X 射线荧光和电感耦合等离子体发射光谱法对膳食补充剂中的元素进行定量

本研究的主要目的是比较通过不同样品制备方法（例如微波辅助湿式消解（MAWD）和悬浮液制备）获得的定量结果。两台配备 Mo X 射线管的全反射 X 射线荧光 (TXRF) 光谱仪用于比较通过两种不同的样品制备路径获得的结果，并进一步与电感耦合等离子体发射光谱法的传统分析方法进行比较。 ICP-OES），包括 MAWD。对三种具有不同组别和浓度元素的膳食补充剂样品进行了分析。强调了样品制备简化路径的优点和局限性。讨论了 TXRF 和 ICP-OES 之间的循环测试。所有测量中回收率百分比的准确度范围为 80 至 120。所有结果的精度对于 TXRF 不超过 8%，对于 ICP-OES 不超过 5%。对于不同元素，TXRF 的定量限范围为 1 至 0.01 毫克/丸。结果表明，样品的悬浮液制备可能是对膳食补充剂质量控制日益增长的需求的有效响应，因为它耗时更少且成本效益高。