Type 2 diabetes (T2D) is a chronic metabolic disorder in which insulin resistance and impaired insulin secretion result in altered metabolite balance, specifically elevated levels of circulating glucose and succinate, which increases the risk of many pathologies, including periodontitis. Succinate, a tricarboxylic acid (TCA) cycle intermediate, can be produced and metabolized by both host cells and host microbiota, where elevated levels serve as an inflammation and pathogen threat signal through activating the succinate G protein-coupled receptor, SUCNR1. Modulating succinate-induced SUCNR1 signaling remains a promising therapeutic approach for pathologies resulting in elevated levels of succinate, such as T2D and periodontitis.

中文翻译：

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一种新型 SUCNR1 抑制剂通过抑制宿主反应来缓解生态失调，而不与宿主微生物群直接相互作用

2 型糖尿病 (T2D) 是一种慢性代谢性疾病，其中胰岛素抵抗和胰岛素分泌受损导致代谢平衡改变，特别是循环葡萄糖和琥珀酸盐水平升高，从而增加了包括牙周炎在内的许多疾病的风险。琥珀酸是一种三羧酸 (TCA) 循环中间体，可由宿主细胞和宿主微生物群产生和代谢，其中升高的水平通过激活琥珀酸 G 蛋白偶联受体 SUCNR1 作为炎症和病原体威胁信号。调节琥珀酸诱导的 SUCNR1 信号传导仍然是治疗导致琥珀酸水平升高的病理学（例如 T2D 和牙周炎）的一种有前途的治疗方法。