The solubilization of butylated hydroxyanisole (BHA) in aqueous surfactant solutions of different architectures (anionic, cationic, and nonionic) has been investigated to improve its aqueous solubility and assess the effect of surfactant-based multiphase environments on its antiradical activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH). Herein, we report that the micellar encapsulation and DDPH antiradical activity of BHA are highly dependent on the structure and amount of surfactant used. Radical scavenging activity (RSA) and solubilization were efficient in nonionics compared to ionics. DPPH reduction kinetics in micellar media is essential to uncover the behavior of BHA in multiphase environments commonly encountered in different food systems simulated by aqueous micelles. The study is important to identify the optimal medium for improving the solubility and antioxidant capacity of compounds like BHA, and to anticipate the effect of different micro-heterogeneous/multiphase environments on BHA's antioxidant capability.

中文翻译：

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丁基羟基苯甲醚在水性表面活性剂胶束中的溶解和 1,1-二苯基-2-三硝基苯肼抗自由基活性

研究了丁基羟基苯甲醚 (BHA) 在不同结构（阴离子、阳离子和非离子）表面活性剂水溶液中的溶解情况，以提高其水溶性并评估基于表面活性剂的多相环境对其抗 1,1- 自由基活性的影响二苯基-2-三硝基苯肼（DPPH）。在此，我们报告 BHA 的胶束封装和 DDPH 抗自由基活性高度依赖于表面活性剂的结构和用量。与离子表面活性剂相比，非离子表面活性剂的自由基清除活性 (RSA) 和增溶作用更有效。胶束介质中的 DPPH 还原动力学对于揭示 BHA 在水性胶束模拟的不同食品系统中常见的多相环境中的行为至关重要。该研究对于确定提高 BHA 等化合物的溶解度和抗氧化能力的最佳介质，以及预测不同微异质/多相环境对 BHA 抗氧化能力的影响具有重要意义。