The COVID-19 pandemic has necessitated rapid research to aid in the understanding of the disease and the development of novel therapeutics. One option is to conduct controlled human infection trials (CHITs). In this article I examine the history of deliberate human infection and CHITs and their utilization prior to the COVID-19 pandemic, key ethical considerations of CHITs in the COVID-19 setting, an analysis of the World Health Organization’s (WHO) Key criteria for the ethical acceptability of COVID-19 human challenge studies, and a review of the two COVID-19 CHITs that have already commenced, their compliance with the WHO criteria and other ethical considerations.

COVID-19 大流行需要快速研究，以帮助了解该疾病和开发新疗法。一种选择是进行受控人体感染试验（CHIT）。在本文中，我研究了故意人类感染和 CHIT 的历史及其在 COVID-19 大流行之前的利用、在 COVID-19 背景下 CHIT 的关键伦理考虑、对世界卫生组织 (WHO) 的关键标准的分析。 COVID-19 人类挑战研究的伦理可接受性，以及对已经开始的两项 COVID-19 CHIT 的审查，它们是否符合 WHO 标准和其他伦理考虑。