This paper presents a facile method to fabricate nanostructured copper-oxide (Cu₂O/CuO) electrodes with columnar morphology for non-enzymatic glucose sensing. The electrodes were fabricated using a two-step method; first by producing Cu nanostructures through glancing angle deposition (GLAD), followed by a thermal annealing process at various temperatures. The nanostructures were characterized by X-ray diffraction and scanning electron microscopy to evaluate their structural and morphological properties. The optical properties of the electrodes were also investigated by VIS/NIR spectroscopy. Electrochemical characterization revealed that Cu₂O outperformed other copper-based nanostructures, with the best sensitivity of 1394 μAcm-2 mM-1 and the lowest limit of detection (LOD) of 0.052 μM. The superior sensor also exhibits two broad linear ranges of 0.01–2 mM and 2–5 mM at the optimized potential of 0.6 V. The Cu₂O electrodes demonstrate the merits of reproducibility, selectivity, fast response time, and high accuracy in measuring glucose levels in real blood serum samples.

本文提出了一种简便的方法来制造具有柱状形态的纳米结构氧化铜（Cu ₂ O/CuO）电极，用于非酶葡萄糖传感。电极采用两步法制造；首先通过掠射角沉积 (GLAD) 生产铜纳米结构，然后在不同温度下进行热退火过程。通过 X 射线衍射和扫描电子显微镜对纳米结构进行表征，以评估其结构和形态特性。还通过可见光/近红外光谱研究了电极的光学性质。电化学表征表明Cu ₂O优于其他铜基纳米结构，最佳灵敏度为1394 μAcm-2 mM-1，最低检测限（LOD）为0.052 μM。该卓越的传感器在 0.6 V 的优化电位下还表现出 0.01–2 mM 和 2–5 mM 两个宽的线性范围。Cu ₂ O 电极在测量葡萄糖方面具有重现性、选择性、快速响应时间和高精度的优点真实血清样本中的水平。