Estrogen plays a key role in the development and progression of many malignant tumours, and the regulation of estrogen levels involves several metabolic pathways. Among these pathways, estrogen sulfotransferase (SULT1E1) is the enzyme with the most affinity for estrogen and is primarily responsible for catalysing the metabolic reaction of estrogen sulphation. Relevant studies have shown significant differences in the expression of SULT1E1 in different malignant tumours, suggesting that SULT1E1 plays a dual role in malignant tumours, both inhibiting the growth of malignant tumours and promoting their development. In addition, the expression level of SULT1E1 may be regulated by a variety of factors, which in turn affect the growth and therapeutic effects of malignant tumours. The aim of this paper is to review the mechanism of action of SULT1E1 in malignant tumours and the mechanisms that are regulated, in order to provide potential targets for the treatment of malignant tumour patients in the future and theoretical support for the realisation of more personalised and effective therapeutic regimens.

中文翻译：

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雌激素磺基转移酶 SULT1E1 在恶性肿瘤中的表达水平和调控因素

雌激素在多种恶性肿瘤的发生、发展中发挥着关键作用，雌激素水平的调节涉及多种代谢途径。在这些途径中，雌激素磺基转移酶（SULT1E1）是与雌激素亲和力最强的酶，主要负责催化雌激素硫酸化的代谢反应。相关研究显示SULT1E1在不同恶性肿瘤中的表达存在显着差异，提示SULT1E1在恶性肿瘤中发挥双重作用，既抑制恶性肿瘤的生长，又促进其发展。此外，SULT1E1的表达水平可能受到多种因素的调节，进而影响恶性肿瘤的生长和治疗效果。本文旨在对SULT1E1在恶性肿瘤中的作用机制及其调控机制进行综述，为今后恶性肿瘤患者的治疗提供潜在靶点，并为实现更加个性化、更个性化的治疗提供理论支持。有效的治疗方案。