Abstract

Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) demonstrate unique abilities for continuous self-renewal and differentiation into all types of somatic cells. Understanding the mechanisms controlling these properties will facilitate an effective and safe introduction of ESCs and iPSCs into cell therapy. Recent data have underscored the importance of proteostasis in the maintenance of ESC function. The present review focuses on the role of ubiquitin-proteasome system (UPS), a key member of proteostasis network, in the regulation of pluripotency and differentiation of ESCs and iPSCs.

中文翻译：

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泛素-蛋白酶体系统在细胞多能性和分化调节中的作用

摘要

胚胎干细胞 (ESC) 和诱导多能干细胞 (iPSC) 表现出持续自我更新和分化为所有类型体细胞的独特能力。了解控制这些特性的机制将有助于将 ESC 和 iPSC 有效且安全地引入细胞治疗中。最近的数据强调了蛋白质稳态在维持 ESC 功能中的重要性。本综述重点关注泛素蛋白酶体系统 (UPS)（蛋白质稳态网络的关键成员）在 ESC 和 iPSC 多能性和分化调节中的作用。