Graft versus host disease (GVHD) remains a major and serious complication of allogeneic hematopoietic stem cell transplantation. Based on the time of onset, clinical phenotypes, progression kinetics, and pathophysiology, GVHD is stratified into acute, chronic, and overlapping types. The eyes are among the most commonly affected organs in GVHD. Mouse models have played an important role in understanding the several key elements of GVHD pathobiology. The current review discusses the immunology, pathology, and key phenotypic features of mouse models of systemic GVHD. Furthermore, a critical appraisal of mouse models of ocular GVHD (oGVHD) is provided. The disease mechanisms underlying the ocular surface, meibomian gland, and lacrimal gland injury in these models are reviewed, and the relevance of oGVHD murine models to clinical oGVHD is also included.

移植物抗宿主病（GVHD）仍然是异基因造血干细胞移植的主要且严重的并发症。根据发病时间、临床表型、进展动力学和病理生理学，GVHD 可分为急性型、慢性型和重叠型。眼睛是 GVHD 最常受影响的器官之一。小鼠模型在理解 GVHD 病理学的几个关键要素方面发挥了重要作用。本综述讨论了系统性 GVHD 小鼠模型的免疫学、病理学和关键表型特征。此外，还提供了眼 GVHD (oGVHD) 小鼠模型的严格评估。对这些模型中眼表、睑板腺和泪腺损伤的疾病机制进行了综述，还包括 oGVHD 小鼠模型与临床 oGVHD 的相关性。