The neural crest is a stem cell population that originates from the ectoderm during the initial steps of nervous system development. Neural crest cells delaminate from the neuroepithelium by undergoing a spatiotemporally regulated epithelial-mesenchymal transition (EMT) that proceeds in a coordinated wave head-to-tail to exit from the neural tube. While much is known about the transcriptional programs and membrane changes that promote EMT, there are additional levels of gene expression control that neural crest cells exert at the level of RNA to control EMT and migration. Yet, the role of post-transcriptional regulation, and how it drives and contributes to neural crest EMT, is not well understood. In this mini-review, we explore recent advances in our understanding of the role of post-transcriptional regulation during neural crest EMT.

中文翻译：

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“超越转录：转录后机制如何驱动神经嵴 EMT”

神经嵴是在神经系统发育的最初步骤中起源于外胚层的干细胞群。神经嵴细胞通过经历时空调节的上皮-间质转化（EMT）从神经上皮分层，该转化以协调的波从头到尾进行，从神经管退出。虽然人们对促进 EMT 的转录程序和膜变化了解很多，但神经嵴细胞在 RNA 水平上发挥额外水平的基因表达控制来控制 EMT 和迁移。然而，转录后调节的作用以及它如何驱动和促进神经嵴 EMT 尚不清楚。在这篇小综述中，我们探讨了对神经嵴 EMT 过程中转录后调节作用的理解的最新进展。