Asprosin, encoded by penultimate two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1), has been recently discovered to be a novel hormone secreted by white adipose tissues during fasting. The glucose metabolism disorders are often accompanied by increased asprosin level. Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis, appetite, insulin secretion, and insulin sensitivity. In this review, we summarize the recent findings from studies on asprosin and its association with Type 2 diabetes mellitus, and discusses its mechanisms from various aspects, so as to provide clinical diagnosis and treatment ideas for T2DM.

白脂素由纤维蛋白 1 (FBN1) 基因的倒数第二个外显子（外显子 65 和外显子 66）编码，最近被发现是禁食期间白色脂肪组织分泌的一种新型激素。葡萄糖代谢紊乱常常伴随着白脂素水平升高。先前的研究表明，白脂素可能通过调节葡萄糖稳态、食欲、胰岛素分泌和胰岛素敏感性来促进糖尿病的发生。本文综述了近年来白脂素及其与2型糖尿病关系的研究成果，并从多方面探讨其作用机制，以期为T2DM的临床诊治提供思路。