The morphological study was aimed at determining the role of fibrillar organization of the collagen-containing connective tissue of prostate cancer at the stage of neoplastic proliferation, including metastatic spreading into bone tissue. The histological material of 55 patients with prostate cancer, Gleason six to nine malignancy score, without neoplastic proliferation and with metastases into bones, was used. The architectural specificities of collagen-containing connective tissue of neoplasms were determined using Van Gieson’s method. It was found that the remodeling of collagen-containing connective tissue around the epithelial tumor structures with aggressive prostate cancer (Gleason score of eight to nine) resulted in the increase in the percentage of extended and flattened fibrils as compared to curved fibrils; the adjacent and surrounding stroma was notable for the enlarged total area of collagen-containing fibrils, manifestations of desmoplasia, compactization of the location, widening, flattening, and extending. The data obtained demonstrate that the remodeling of collagen-containing connective tissue components of prostate cancer conditions unrestricted migration and invasion of tumor cells, including those expressing the proteins involved in bone tissue remodeling.

形态学研究的目的是确定前列腺癌含胶原结缔组织的纤维组织在肿瘤增殖阶段（包括转移扩散到骨组织中）的作用。使用 55 名前列腺癌患者的组织学材料，格里森恶性评分为 6 至 9，无肿瘤增殖且有骨转移。使用 Van Gieson 的方法确定了肿瘤的含胶原结缔组织的结构特异性。研究发现，侵袭性前列腺癌（格里森评分为 8 至 9）的上皮肿瘤结构周围含胶原结缔组织的重塑导致延长和扁平原纤维的百分比比弯曲原纤维增加；邻近和周围基质的显着特征是含胶原原纤维的总面积增大、结缔组织增生的表现、位置的致密化、加宽、变平和延伸。获得的数据表明，前列腺癌的含胶原结缔组织成分的重塑条件是肿瘤细胞不受限制的迁移和侵袭，包括那些表达参与骨组织重塑的蛋白质的细胞。结缔组织增生的表现，部位致密化、变宽、变平、延伸。获得的数据表明，前列腺癌的含胶原结缔组织成分的重塑条件是肿瘤细胞不受限制的迁移和侵袭，包括那些表达参与骨组织重塑的蛋白质的细胞。结缔组织增生的表现，部位致密化、变宽、变平、延伸。获得的数据表明，前列腺癌的含胶原结缔组织成分的重塑条件是肿瘤细胞不受限制的迁移和侵袭，包括那些表达参与骨组织重塑的蛋白质的细胞。