The filamentous fungus Synnemellisia sp. strain FKR-0921 was obtained from soil collected on Kume Island, Okinawa. The MeOH extract of FKR-0921 cultured on a solid rice medium yielded a new aromatic compound, synnemellisitriol A (1). The structure, including the absolute configuration, was elucidated by spectroscopic analysis (FT-IR, NMR, and HR-ESI-MS), and the absolute configuration at C-9 of 1 was determined using the modified Mosher’s method. Additionally, 1 was evaluated for its biological activities, including metallo-β-lactamase inhibitory activity, type III secretion system inhibitory activity, antimicrobial activity, antimalarial activity, and cytotoxicity.

丝状真菌Synnemellisia sp。菌株FKR-0921是从冲绳久米岛收集的土壤中获得的。在固体大米培养基上培养的 FKR-0921 的甲醇提取物产生了一种新的芳香化合物，synnemellisitriol A ( 1 )。通过光谱分析（FT-IR、NMR 和 HR-ESI-MS）阐明了包括绝对构型在内的结构，并使用改进的 Mosher 方法确定了1的 C-9 处的绝对构型。此外，还评估了1的生物活性，包括金属-β-内酰胺酶抑制活性、III型分泌系统抑制活性、抗菌活性、抗疟活性和细胞毒性。