Introduction OnabotulinumtoxinA for migraine involves 31 injected repeated every 12 weeks. Tolerability is a significant factor impacting discontinuation. Music medicine has not been studied previously as an intervention to improve the tolerability of injections. Methodology A single-centre prospective cohort study was undertaken. Following baseline, patients had music played during the procedure. Change in Visual Analogue Score (VAS) was assessed as the primary outcome. Results Over 6 months, 50 patients were recruited with a median age of 42, and median duration of therapy of 13.5 months. ‘Quiet calm classical music’ was associated with a significant reduction in VAS (z=−4.7, p<0.001). Duration of therapy, disease state or headache frequency had no correlation with change in VAS. Conclusion Music medicine is associated with a significant reduction in the procedural pain of onabotulinumtoxinA injections in prospective study. Further study is required to explore other modifiable factors to improve patient experience. Data are available upon reasonable request. The dataset for this manuscript will be made available upon reasonable request subject to appropriate ethics submission and approval.

中文翻译：

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音乐医学提高 A 型肉毒杆菌毒素注射治疗慢性偏头痛的耐受性：一项开放标签前瞻性队列研究

简介 治疗偏头痛的 OnabotulinumtoxinA 需要每 12 周重复注射 31 次。耐受性是影响停药的重要因素。此前尚未将音乐医学作为提高注射耐受性的干预措施进行研究。方法学进行了一项单中心前瞻性队列研究。在基线之后，患者在手术过程中播放音乐。视觉模拟评分（VAS）的变化被评估为主要结果。结果 6 个月内，招募了 50 名患者，中位年龄为 42 岁，中位治疗持续时间为 13.5 个月。“安静的古典音乐”与 VAS 的显着降低相关（z=-4.7，p<0.001）。治疗持续时间、疾病状态或头痛频率与 VAS 的变化没有相关性。结论 在前瞻性研究中，音乐医学与 A 型肉毒杆菌毒素注射操作疼痛的显着减轻相关。需要进一步研究探索其他可改变的因素以改善患者体验。数据可根据合理要求提供。本手稿的数据集将根据合理要求提供，但须经过适当的道德提交和批准。