Objective Staphylococcus capitis , a coagulase-negative staphylococci (CoNS) species, has been increasingly detected from UK sterile site samples and has caused neonatal unit outbreaks worldwide. We compared survival to discharge and 30-day mortality for the detection of S. capitis versus other CoNS species. Methods In this retrospective case–control study, we included hospitalised infants with any CoNS species detected from a normally sterile body site up to 90 days of age. We linked English laboratory reports from the Second Generation Surveillance System database, mortality data from the Personal Demographics Service, and neonatal unit admissions from the National Neonatal Research Database. In primary analysis, multivariable logistic regression was used, with two co-primary outcomes: survival to discharge and death within 30 days of positive specimen date. Sensitivity analyses using multiply imputed datasets followed. Results We identified 16 636 CoNS episodes relating to 13 745 infants. CoNS episodes were highest among infants born extremely preterm (22–27 weeks) and with extremely low birth weight (400–999 g). In primary analysis, there were no differences in survival to discharge (p=0.71) or 30-day mortality (p=0.77) between CoNS species. In sensitivity analyses, there were no differences in outcomes between infection with four of the most common CoNS species ( Staphylococcus epidermidis, S. capitis , Staphylococcus haemolyticus and Staphylococcus warneri ) but the remaining CoNS species were at higher risk of adverse outcomes when treated in aggregate. Conclusion Infants with S. capitis detected from sterile site samples did not experience significant differences in either survival to discharge or 30-day mortality compared with infants with detection of other common CoNS species. Data are available upon reasonable request. UKHSA operates a robust governance process for applying to access protected data. Further details can be found at .

中文翻译：

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2015-2021 年英国新生儿头状葡萄球菌分离的临床结果：回顾性病例对照研究

目的 头状葡萄球菌是一种凝固酶阴性葡萄球菌 (CoNS) 物种，越来越多地从英国无菌场所样本中检出，并已在全球范围内引起新生儿单位暴发。我们比较了头链球菌与其他 CoNS 物种的检测出院存活率和 30 天死亡率。方法 在这项回顾性病例对照研究中，我们纳入了 90 天内在正常无菌身体部位检测到任何 CoNS 物种的住院婴儿。我们将第二代监测系统数据库中的英文实验室报告、个人人口统计服务中的死亡率数据以及国家新生儿研究数据库中的新生儿病房入院情况联系起来。在主要分析中，使用多变量逻辑回归，有两个共同主要结果：出院时的存活率和阳性标本日期后 30 天内的死亡。随后使用多重插补数据集进行敏感性分析。结果 我们确定了与 13 745 名婴儿相关的 16 636 次 CoNS 发作。CoNS 发作在极早产（22-27 周）和极低出生体重（400-999 克）的婴儿中最高。在初步分析中，CoNS 物种之间的出院生存率 (p=0.71) 或 30 天死亡率 (p=0.77) 没有差异。在敏感性分析中，四种最常见的 CoNS 物种（表皮葡萄球菌、头状葡萄球菌、溶血葡萄球菌和华氏葡萄球菌）感染的结果没有差异，但其余 CoNS 物种在综合治疗时出现不良结果的风险较高。结论 与检测到其他常见 CoNS 物种的婴儿相比，从无菌场所样本中检测到头链球菌的婴儿在出院存活率或 30 天死亡率方面没有显着差异。数据可根据合理要求提供。UKHSA 实行健全的治理流程来申请访问受保护的数据。更多详情请参见。