Autologous grafts represent the gold standard for regenerated tissues after diseases, trauma or defects. However, the main problems of this strategy are availability, donor site morbidity and postoperative complications. For this reason, a new approach in tissue engineering looks at scaffolds obtained through the decellularization of native extracellular matrices as an alternative technology to circumvent these limitations. Thus, this review aims to focus on the potential for use of acellular grafts, particularly on the methods of decellularization and recellularization, and continues with their application as part of the formulation of bioinks, which would represent a breakthrough in the field of biofabrication due to their naturally bioactive composition, preserving tissue architecture and structural integrity as a potential alternative for tissue regeneration.

中文翻译：

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无细胞移植支架作为组织再生替代品的策略

自体移植代表了疾病、创伤或缺陷后再生组织的黄金标准。然而，该策略的主要问题是可用性、供体部位发病率和术后并发症。因此，组织工程中的一种新方法着眼于通过天然细胞外基质的脱细胞化获得的支架作为规避这些限制的替代技术。因此，本综述旨在重点关注无细胞移植物的使用潜力，特别是去细胞化和再细胞化的方法，并继续将其应用作为生物墨水配方的一部分，这将代表生物制造领域的突破，因为它们的天然生物活性成分，保留组织结构和结构完整性，作为组织再生的潜在替代品。