Here we provide a summary of a plenary lecture delivered on Mycobacterium bovis, the bovine TB bacillus, at the M. bovis 2022 meeting held in Galway, Ireland, in June 2022. We focus on the analysis of genetic differences between M. bovis and the human pathogen Mycobacterium tuberculosis as a route to gain knowledge on what makes M. bovis function as an animal pathogen. We provide a brief historical background around M. bovis and comparative virulence experiments with M. tuberculosis, before moving to what we have learned from the studies of the M. bovis genome sequence. We discuss the need to translate knowledge on the molecular basis of virulence in M. bovis into improved control of bovine tuberculosis.

中文翻译：

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探索牛分枝杆菌的毒力：比较基因组学的线索和未来的展望

在此，我们提供了 2022 年 6 月在爱尔兰戈尔韦举行的 2022 年牛分枝杆菌会议上关于牛分枝杆菌（牛结核杆菌）的全体演讲的摘要。我们重点分析牛分枝杆菌和牛分枝杆菌之间的遗传差异。人类病原体结核分枝杆菌是获取牛分枝杆菌作为动物病原体的知识的途径。在讨论我们从牛分枝杆菌基因组序列研究中学到的知识之前，我们简要介绍了牛分枝杆菌的历史背景以及结核分枝杆菌的毒力比较实验。我们讨论了将牛分枝杆菌毒力的分子基础知识转化为改善牛结核病控制的必要性。