Importance Few recent studies have examined neurocognitive functioning (NCF) in patients with sinonasal and nasopharyngeal cancers (NPCs) prior to and following multimodality therapy or the potential differences in NCF by disease variables such as disease site. Objective The objective of this study is to determine rates of NCF impairments prior to and following multimodality therapy, declines in NCF following radiotherapy (RT), and possible differences in NCF by the disease site. Design, Setting, and Participants We conducted a retrospective chart review of 39 patients with sinonasal and NPCs who underwent comprehensive neuropsychological evaluations. Twenty patients were evaluated prior to RT, of which eleven received follow-up evaluation after completion of RT. Nineteen patients were evaluated following various treatments without a pre-RT evaluation. Main Outcomes and Measures Patients completed comprehensive neuropsychological evaluations. Decline from pre-RT to follow-up was defined on the basis of reliable change indices. Results Thirty-nine patients completed comprehensive neuropsychological evaluations. For the entire cohort, the most frequently demonstrated impairments were in verbal memory (47%) and learning (43%), executive functioning (33%), and verbal fluency (22%). At post-RT follow-up, the most frequently observed declines were in verbal learning (46%) and memory (18%). Demographic and disease variables were not significantly associated with NCF at pre-RT or post-RT. Conclusion and Relevance Patients with sinonasal and NPCs are at risk for NCF impairments in multiple areas at baseline and memory decline following RT. Future prospective studies are needed to investigate the impact of each treatment modality on NCF and specific risk factors for cognitive dysfunction.

中文翻译：

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多学科治疗鼻窦癌和鼻咽癌患者的神经认知功能

重要性 最近很少有研究检查鼻窦癌和鼻咽癌 (NPC) 患者在多模式治疗之前和之后的神经认知功能 (NCF) 或不同疾病变量（例如疾病部位）的 NCF 潜在差异。目的 本研究的目的是确定多学科治疗前后 NCF 损伤的发生率、放疗 (RT) 后 NCF 的下降情况以及不同疾病部位 NCF 可能存在的差异。设计、环境和参与者 我们对 39 名鼻窦和鼻咽癌患者进行了回顾性图表审查，这些患者接受了全面的神经心理学评估。20 名患者在放疗前接受了评估，其中 11 名患者在放疗完成后接受了随访评估。十九名患者在接受各种治疗后接受评估，但未进行 RT 前评估。主要结果和措施患者完成了全面的神经心理学评估。从 RT 前到随访的​​下降是根据可靠的变化指数定义的。结果 39 名患者完成了全面的神经心理学评估。对于整个队列，最常见的障碍是语言记忆（47%）和学习（43%）、执行功能（33%）和语言流畅性（22%）。在 RT 后随访中，最常见的下降是言语学习（46%）和记忆力（18%）。人口统计学和疾病变量与 RT 前或 RT 后的 NCF 没有显着相关性。结论和相关性 鼻窦炎和鼻咽癌患者在基线时存在多个区域 NCF 损伤和放疗后记忆力下降的风险。未来需要进行前瞻性研究来调查每种治疗方式对 NCF 的影响以及认知功能障碍的具体危险因素。