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Nano-phototherapy: Favorable prospects for cancer treatment
WIREs Nanomedicine and Nanobiotechnology ( IF 8.6 ) Pub Date : 2023-09-26 , DOI: 10.1002/wnan.1930
J P Jose Merlin 1 , Anine Crous 1 , Heidi Abrahamse 1
Affiliation  

Nanotechnology-based phototherapies have drawn interest in the fight against cancer because of its noninvasiveness, high flexibility, and precision in terms of cancer targeting and drug delivery based on its surface properties and size. Phototherapy has made remarkable development in recent decades. Approaches to phototherapy, which utilize nanomaterials or nanotechnology have emerged to contribute to advances around nanotechnologies in medicine, particularly for cancers. A brief overviews of the development of photodynamic therapy as well as its mechanism in cancer treatment is provided. We emphasize the design of novel nanoparticles utilized in photodynamic therapy while summarizing the representative progress during the recent years. Finally, to forecast important future research in this area, we examine the viability and promise of photodynamic therapy systems based on nanoparticles in clinical anticancer treatment applications and briefly make mention of the elimination of all reactive metabolites pertaining to nano formulations inside living organisms providing insight into clinical mechanistic processes. Future developments and therapeutic prospects for photodynamic treatments are anticipated. Our viewpoints might encourage scientists to create more potent phototherapy-based cancer therapeutic modalities.

中文翻译:

纳米光疗:癌症治疗的良好前景

基于纳米技术的光疗法因其无创性、高度灵活性以及基于其表面特性和尺寸的癌症靶向和药物输送的精确性而引起了人们对抗癌的兴趣。近几十年来,光疗法取得了显着的发展。利用纳米材料或纳米技术的光疗方法已经出现,有助于推动医学纳米技术的进步,特别是在癌症方面。简要概述了光动力疗法的发展及其在癌症治疗中的机制。我们重点介绍了用于光动力治疗的新型纳米粒子的设计,同时总结了近年来的代表性进展。最后,为了预测该领域未来的重要研究,我们研究了基于纳米粒子的光动力治疗系统在临床抗癌治疗应用中的可行性和前景,并简要提到了消除与生物体内纳米制剂有关的所有反应性代谢物,从而深入了解临床机制过程。预计光动力治疗的未来发展和治疗前景。我们的观点可能会鼓励科学家创造更有效的基于光疗的癌症治疗方式。
更新日期:2023-09-26
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