Brain tumours are heterogeneous and are classified comprehensively into molecular subtypes based on genetic alterations. Glioblastoma rapid progression, drug resistance, and recurrence have been scientifically linked to several factors, including its rapid growth rate, loss of apoptosis, pro-survival signalling, molecular heterogeneities and hallmark features to infiltrate vital brain structures. Because of the growing demand for design and development of delivery systems to overcome the existing limitations with the current therapeutic strategies, researchers are exploiting multifaceted aspects of nanotechnology to improve delivery of the drug payload. Firstly, nanotechnology procedures can improve the drug delivery methods with the help of nanoparticles (NPs) based nanovectors that can efficiently cross blood-brain barrier. Secondly, NPs also improve the cellular uptake of the drug as they can efficiently bind with the cell surface. Thirdly, NPs make the delivery of siRNAs and peptides possible, which can suppress the resistance of glioblastoma against TMZ or other chemo-preventive drugs. Fourthly, the use of metal NPs increases the efficiency of scanning or magnetic resonance imaging (MRI) procedures as they can produce contrasts in it. Lastly, NPs make it possible to use highly targeted co-administered strategies like chemoprevention and near infrared (NIR) or radiotherapy (RT). Hence, nanotechnology offers several promising solutions against glioblastoma by countering it on many fronts.

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基于纳米技术的胶质母细胞瘤癌症化学预防

脑肿瘤具有异质性，根据基因改变可全面分为分子亚型。胶质母细胞瘤的快速进展、耐药性和复发与多种因素有关，包括其快速生长速度、细胞凋亡丧失、促生存信号传导、分子异质性和浸润重要大脑结构的标志特征。由于对设计和开发递送系统以克服当前治疗策略的现有限制的需求不断增长，研究人员正在利用纳米技术的多方面来改善药物有效负载的递送。首先，纳米技术程序可以借助基于纳米颗粒（NP）的纳米载体来改善药物输送方法，这些纳米载体可以有效地穿过血脑屏障。其次，纳米颗粒还可以提高药物的细胞摄取，因为它们可以有效地与细胞表面结合。第三，纳米粒子使得siRNA和肽的递送成为可能，这可以抑制胶质母细胞瘤对TMZ或其他化疗预防药物的耐药性。第四，金属纳米粒子的使用提高了扫描或磁共振成像（MRI）程序的效率，因为它们可以在其中产生对比度。最后，纳米粒子使得使用化学预防和近红外（NIR）或放射治疗（RT）等高度针对性的联合治疗策略成为可能。因此，纳米技术通过在许多方面对抗胶质母细胞瘤，提供了几种有前景的解决方案。