A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization,mAbs

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A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization
mAbs ( IF 5.3 ) Pub Date : 2023-09-27 , DOI: 10.1080/19420862.2023.2261149
Paul Arras _{1,

2} , Han Byul Yoo _{1,

3} , Lukas Pekar ₁ , Christian Schröter ₄ , Thomas Clarke ₅ , Simon Krah ₁ , Daniel Klewinghaus ₃ , Vanessa Siegmund ₃ , Andreas Evers ₁ , Stefan Zielonka _{1,

2}

Affiliation

In this study, we generated a novel library approach for high throughput de novo identification of humanized single-domain antibodies following camelid immunization. To achieve this, VHH-derived co...

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