Preserving bone health is an important goal of care of patients with acromegaly and growth hormone deficiency (GHD). Both disorders are associated with compromised bone health and an increased risk of fracture. However, parameters of bone health that are routinely used to predict fractures in other populations, such as aBMD measured by DXA, are unreliable for this in acromegaly and GHD. Additional methodologies need to be employed to assess bone health in these patients. This review summarizes available data on the effects of acromegaly and GHD on parameters of bone health such as aBMD, volumetric bone mineral density (vBMD) and microarchitecture assessed by HRpQCT and other techniques, trabecular bone score (TBS) and fracture assessment. More research is needed to identify reliable predictors of fracture risk and to determine how best to screen for and treat those patients at risk so that bone health is optimized in these patients.

保持骨骼健康是肢端肥大症和生长激素缺乏症 (GHD)患者的重要护理目标。这两种疾病都与骨骼健康受损和骨折风险增加有关。然而，常规用于预测其他人群骨折的骨骼健康参数（例如通过DXA测量的 aBMD ）对于肢端肥大症和 GHD 来说并不可靠。需要采用其他方法来评估这些患者的骨骼健康状况。本综述总结了肢端肥大症和 GHD 对骨骼健康参数的影响的现有数据，例如 aBMD、体积骨矿物质密度 (vBMD) 和通过 HRpQCT 和其他技术评估的微结构、骨小梁评分 (TBS) 和骨折评估。需要更多的研究来确定骨折风险的可靠预测因素，并确定如何最好地筛查和治疗有风险的患者，以便优化这些患者的骨骼健康。