Camelpox is an important viral disease of dromedary camel in Rajasthan, India. In the present study, partial C18L gene sequences (n = 6) of camelpox virus (CMLV) obtained in an outbreak in Bikaner, Rajasthan, India in year 2022 were compared with other similar sequences obtained in the past in similar geographical location. Clinical and epidemiological features of the disease were also compared. Genomic study suggested variations in C18L gene sequences obtained in the present outbreak from those obtained during the past outbreaks. CMLV were genetically different from cowpox viruses, but appeared identical to CMLV causing disease in Israel, Egypt and Kazakhstan. Genomes of CMLV virus circulating in dromedary camel population of Rajasthan, India appeared diverse and changing, hence complete genome sequencing and identification of genomic changes altering infectivity and pathogenicity is warranted for designing control strategies.

中文翻译：

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印度拉贾斯坦邦单峰骆驼种群中传播的骆驼痘病毒的分子研究

骆驼痘是印度拉贾斯坦邦单峰骆驼的一种重要病毒性疾病。在本研究中，将 2022 年印度拉贾斯坦邦比卡内尔爆发的骆驼痘病毒 (CMLV) 的部分 C18L 基因序列 (n = 6) 与过去在类似地理位置获得的其他类似序列进行了比较。还比较了该疾病的临床和流行病学特征。基因组研究表明，本次疫情中获得的 C18L 基因序列与过去疫情中获得的序列存在差异。CMLV 在基因上与牛痘病毒不同，但与在以色列、埃及和哈萨克斯坦引起疾病的 CMLV 似乎相同。在印度拉贾斯坦邦的单峰骆驼种群中传播的 CMLV 病毒的基因组表现出多样性和变化性，因此完整的基因组测序和识别改变感染性和致病性的基因组变化对于设计控制策略是必要的。