Over the past thirty years, the International Workshops on Genotoxicity Testing (IWGT) became one of the leading groups in the field of regulatory genotoxicology, not only due to the diversity of participants with respect to geography and professional affiliation, but also due to the unique setup of recurring IWGT meetings every four years. The hallmarks of the IWGT process have been diligent initial planning approaches of the working groups, collection of data so as to stimulate data-driven discussions and debate, and striving to reach consensus recommendations. The scientific quality of the Working Groups (WGs) has been exceptional due to the selection of highly regarded experts on each topic. As a result, the IWGT working group reports have become important documents. The deliberations and publications have provided guidance on test systems and testing protocols that have influenced the development or revision of test guidelines of the Organization for Economic Co-operation and Development (OECD), guidance by the International Council for Harmonisation (ICH), and strategic testing or data analysis approaches in general. This article summarizes the history of the IWGT, identifies some of its major achievements, and provides an outlook for the future.

在过去的三十年中，国际基因毒性测试研讨会（IWGT）成为监管基因毒理学领域的领先团体之一，这不仅是因为参与者在地理和专业背景方面的多样性，而且还因为独特的每四年召开一次 IWGT 会议。IWGT 流程的特点是工作组勤勉的初步规划方法、收集数据以激发数据驱动的讨论和辩论，并努力达成共识建议。由于每个主题都选出了备受推崇的专家，因此工作组 (WG) 的科学质量非常出色。因此，IWGT工作组报告已成为重要文件。这些审议和出版物为测试系统和测试协议提供了指导，这些指导影响了经济合作与发展组织 (OECD) 测试指南的制定或修订、国际协调委员会 (ICH) 的指导以及战略一般测试或数据分析方法。本文总结了 IWGT 的历史，确定了其一些主要成就，并对未来进行了展望。