Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown. We retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses. We found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients. Our present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development.

中文翻译：

---

免疫性血小板减少症中的高脂血症：一项回顾性研究

免疫性血小板减少症（ITP）是一种自身免疫性出血性疾病，以血小板计数低和出血表现为特征。但也有部分患者出现动脉粥样硬化，甚至梗塞。除了活化的血小板外，脂质代谢在动脉粥样硬化和代谢综合征的形成中也起着很大的作用。ITP患者的脂质代谢状态仍不清楚。我们回顾性分析了队列中 302 名住院 ITP 患者，比较了他们的血脂、出血症状、代谢疾病和治疗反应。我们发现很高比例的ITP患者患有高脂血症以及其他代谢性疾病，包括心血管或脑动脉粥样硬化或梗塞、高血压和2型糖尿病。高脂血症与 ITP 的严重出血和治疗难治性相关。他汀类药物可以缓解血小板减少和出血严重程度，促进ITP治疗，同时改善ITP患者的高脂血症。我们目前的研究表明，脂质代谢可能在 ITP 的发病机制和发展中发挥着不可或缺的作用。