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Green Synthetic Methods of Oxazine and Thiazine Scaffolds as Promising Medicinal Compounds: A Mini-Review
Current Organic Synthesis ( IF 1.8 ) Pub Date : 2023-10-02 , DOI: 10.2174/1570179420666230811092847
Abdulelah Aljuaid 1 , Mamdouh Allahyani 1 , Ahad Amer Alsaiari 1 , Mazen Almehmadi 1 , Abdulaziz Alsharif 1 , Mohammad Asif 2
Affiliation  

: Medical researchers have paid close attention to the green synthesis of oxazine and thiazine derivatives since they provided a lead molecule for the creation of numerous possible bioactive compounds. This review provides more information on green synthesis, which will be very helpful to researchers in creating the most effective, affordable, and clinically significant thiazine and oxazine derivatives that are anticipated to have strong pharmacological effects. This has resulted in the identification of several substances with a wide range of intriguing biological functions. This article's goal is to examine the numerous green chemical processes used to create oxazine and thiazine derivatives and their biological activity. We anticipate that researchers interested in oxazine and thiazine chemicals will find this material to be useful. We anticipate that medicinal chemists looking for new active medicinal components for drug discovery and advance progress will find this review of considerable interest.

中文翻译:

恶嗪和噻嗪支架作为有前途的药物化合物的绿色合成方法:小综述

:医学研究人员密切关注恶嗪和噻嗪衍生物的绿色合成,因为它们为创造许多可能的生物活性化合物提供了先导分子。这篇综述提供了更多关于绿色合成的信息,这对于研究人员创造最有效、最实惠且具有临床意义的噻嗪和恶嗪衍生物非常有帮助,这些衍生物预计具有很强的药理作用。这导致了几种具有广泛有趣的生物功能的物质的鉴定。本文的目标是研究用于制造恶嗪和噻嗪衍生物的众多绿色化学工艺及其生物活性。我们预计对恶嗪和噻嗪化学品感兴趣的研究人员会发现这种材料很有用。我们预计,寻找新的活性药物成分以进行药物发现和推进进展的药物化学家将会对这篇综述感兴趣。
更新日期:2023-10-02
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