HIV infection is known to have significant effects on central nervous system. This study conducted a meta-analysis of whole voxel-based morphometry (VBM) in HIV patients (N = 435) and HIV-uninfected controls (N = 397). This study observed a reduction of limbic lobe, cingulate gyrus, frontal lobe, middle frontal gyrus, sub-lobar, insula, inferior frontal gyrus and superior frontal gyrus volume in HIV patients. These morphological differences may be responsible for cognitive decline in HIV patients, as these brain regions are closely related to motor and memory functions. These results contribute to a better understanding of the neural mechanisms underlying brain injury in HIV patients and could help develop targeted brain targets, provide more personalized treatment and predict neurodevelopmental outcomes.

已知艾滋病毒感染对中枢神经系统有显着影响。本研究对 HIV 患者 ( N  = 435) 和未感染 HIV 的对照组 ( N = 397)进行了基于整体体素的形态测量 (VBM) 的荟萃分析 。这项研究观察到艾滋病毒患者的边缘叶、扣带回、额叶、额中回、叶下、岛叶、额下回和额上回体积减少。这些形态差异可能是艾滋病毒患者认知能力下降的原因，因为这些大脑区域与运动和记忆功能密切相关。这些结果有助于更好地了解艾滋病毒患者脑损伤的神经机制，并有助于开发有针对性的大脑目标，提供更个性化的治疗并预测神经发育结果。