Recent years have seen increasing attention paid to the microarchitecture of bones. Together with bone density, it is an essential determinant of mechanical strength. Bone microarchitecture adapts to mechanical stress, as well as to age and sex effects. Furthermore, the structural properties of bone compromised by different mechanical stresses make it difficult to understand the coupling between the accumulation of mechanically induced damage and the biological functions of bone. The model study can be applied to investigate the interrelationship between remodeling and biological factors involved in determining mineral movement in bone. The mechanism of the biological factors is related to the surface area available for remodeling and the density of the area in question. Furthermore, it has been shown that age has an impact on the capacity of mechanical transduction of bone cells and on the effect of the mechanical stimulus applied to osteocytes has been taken into account. This research was developed to numerically analyses the impact of mechanical properties in bone remodeling process under cyclic loading represented by various physical activity situations, revealing an intermediate region of bone tissue showing a variation in apparent density with age depending on the mineralisation level.

中文翻译：

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使用有限元对皮质/海绵体界面进行多尺度力学建模

近年来，人们越来越关注骨骼的微结构。它与骨密度一起是机械强度的重要决定因素。骨微结构适应机械应力以及年龄和性别的影响。此外，骨的结构特性受到不同机械应力的影响，使得很难理解机械引起的损伤的积累与骨的生物学功能之间的耦合。该模型研究可用于研究重塑与决定骨中矿物质运动的生物因素之间的相互关系。生物因素的机制与可用于重塑的表面积和相关区域的密度有关。此外，已经表明，年龄对骨细胞的机械转导能力有影响，并且已经考虑到了对骨细胞施加的机械刺激的影响。这项研究的目的是对以各种身体活动情况为代表的循环载荷下骨重塑过程中机械性能的影响进行数值分析，揭示骨组织的中间区域显示出表观密度随年龄的变化，具体取决于矿化水平。