In the present study, we report the complete genome of five Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from Bangladesh harboring mutations at Spike protein (E484K, Q677H, D614G, A67V, Q52R, Y144del, H69del, V70del, F888L) assigned to the B.1.525 lineage (Variant of interest). Mutations are also found in viral structural proteins other than spike region (E_L21F, M_I82F, N_A12G and N_T208I) and other mutations (NSP3_T1189I, NSP6_S106del, NSP6_F108del, NSP6_G107del, NSP12_P323F) from all of five B.1.525 SARS-CoV-2 variants of Bangladesh. We have also found four unique mutations from two of SARS-CoV-2 B.1.525 variant of Bangladesh. Among the four unique mutations two mutations (NS7a_L96H, NS7a_Y97D) obtained from strain BCSIR-NILMRC-718, one (NSP3_A1430V) from BCSIR-NILMRC-738 and two mutation including one spike protein mutation (NSP2_L444I, Spike_I68 M) present in BCSIR-AFIP-10 strain. The identification of new mutations will contribute to characterizing SARS-CoV-2, to continue tracking its spread and better understanding its biological and clinical features to take medical countermeasures and vaccines.

在本研究中，我们报告了来自孟加拉国的五种严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 的完整基因组，其中包含刺突蛋白突变（E484K、Q677H、D614G、A67V、Q52R、Y144del、H69del、V70del、F888L ）分配给 B.1.525谱系（感兴趣的变体）。孟加拉国所有 5 种 B.1.525 SARS-CoV-2 变种的病毒结构蛋白（E_L21F、M_I82F、N_A12G 和 N_T208I）以及其他突变（NSP3_T1189I、NSP6_S106del、NSP6_F108del、NSP6_G107del、NSP12_P323F）中也发现了突变。我们还发现了孟加拉国两种 SARS-CoV-2 B.1.525 变种的四种独特突变。在四种独特突变中，两种突变（NS7a_L96H、NS7a_Y97D）来自菌株 BCSIR-NILMRC-718，一种突变（NSP3_A1430V）来自 BCSIR-NILMRC-738，两种突变包括 BCSIR-AFIP 中存在的一种刺突蛋白突变（NSP2_L444I、Spike_I68 M） -10应变。新突变的识别将有助于表征 SARS-CoV-2，继续追踪其传播并更好地了解其生物学和临床特征，以采取医疗对策和疫苗。