It is still debated whether arterial elasticity provides prognostic information for cardiovascular risk beyond blood pressure measurements in a healthy population. To investigate the association between arterial elasticity obtained by radial artery pulse wave analysis and risk for cardiovascular diseases (CVD) in men and women. In 2002–2005, 2362 individuals (men=1186, 50.2%) not taking antihypertensive medication were included. C2 (small artery elasticity) was measured using the HDI/Pulse Wave CR2000. Data on acute myocardial infarction or stroke, fatal or non-fatal, was obtained between 2002–2019. Cox- regression was used to investigate associations between C2 and future CVD, adjusting for confounding factors such as age, sex, systolic blood pressure, heart rate, HOMA-IR (Homeostatic Model Assessment for Insulin Resistance), LDL- cholesterol, CRP (C-Reactive Protein), alcohol consumption, smoking and physical activity. At baseline, the mean age of 46 ± 10.6 years and over the follow-up period, we observed 108 events 70 events in men [event rate: 5.9%], 38 in women [event rate: 3.2%]. In the fully adjusted model, and for each quartile decrease in C2, there was a significant increase in the risk for incident CVD by 36%. (HR = 1.36, 95% CI: 1.01–1.82, p = 0.041). The results were accentuated for all men (HR = 1.74, 95% CI: 1.21–2.50, p = 0.003) and women over the age of 50 years (HR = 1.70, 95% CI: 0.69–4.20). We showed a strong and independent association between C2 and CVD in men. In women after menopause, similar tendencies and effect sizes were observed.

除了健康人群的血压测量之外，动脉弹性是否可以提供心血管风险的预后信息仍然存在争议。研究通过桡动脉脉搏波分析获得的动脉弹性与男性和女性心血管疾病 (CVD) 风险之间的关联。2002-2005 年，2362 名未服用抗高血压药物的个体（男性=1186，50.2%）被纳入研究。使用 HDI/Pulse Wave CR2000 测量C2（小动脉弹性） 。有关急性心肌梗死或中风（致命或非致命）的数据是在 2002 年至 2019 年期间获得的。Cox回归用于研究C2与未来CVD之间的关联，调整混杂因素，例如年龄、性别、收缩压、心率、HOMA-IR（胰岛素抵抗稳态模型评估）、LDL-胆固醇、CRP（C -反应蛋白）、饮酒、吸烟和体力活动。在基线时，平均年龄为 46 ± 10.6 岁，在随访期间，我们观察到 108 起事件，其中 70 起男性事件 [事件发生率：5.9%]，38 起女性事件 [事件发生率：3.2%]。在完全调整的模型中，C2 每下降四分位，CVD 风险就会显着增加 36%。（HR = 1.36，95% CI：1.01–1.82，p  = 0.041）。对于所有男性（HR = 1.74，95% CI：1.21–2.50，p  = 0.003）和 50 岁以上女性（HR = 1.70，95% CI：0.69–4.20），这一结果更为明显。我们发现男性 C2 和 CVD 之间存在很强且独立的关联。在绝经后的女性中，观察到类似的趋势和效应大小。