The double-lumen cannula (DLC) is the most critical component of extracorporeal membrane oxygenation (ECMO) because of its narrow cross-section, thereby developing the highest shear stress in the entire ECMO circuit. To measure blood damage in a DLC, the Eulerian approach is generally used without contemplating exposure time or history of blood exposure to shear stresses. Alternatively, Lagrangian approach has also been recently employed for a Newtonian blood flow through a DLC, thereby leaving a research gap on the impact of variable shear rate in case of non-Newtonian blood flow. In the present study, the hemodynamic performance of DLC is investigated using different non-Newtonian models by applying Lagrangian approach. Moreover, the motion of RBC was tracked inside the cannula to predict its behavior during the motion. The results showed that the return lumen had higher pressure, velocity, and shear stress values than other parts of the DLC. In addition, recirculation was observed due to the mixing of blood coming from different inlets and found increase with increasing flow rate of blood. Moreover, it was found that the blood damage increased with increasing flow rate. There was more blood damage in the Newtonian model than in the other non-Newtonian models at higher flow rates. However, the Carreau model showed more blood damage at lower flow rates than the other models. The Cross model showed DLC’s higher efficacy in delivering oxygenated blood to the tricuspid outlet because it showed the least blood damage among all other models. It was also concluded that the efficacy of the DLC to deliver oxygenated blood to the tricuspid outlet decreases with increasing blood flow rate.

双腔插管（DLC）因其横截面狭窄而成为体外膜肺氧合（ECMO）最关键的组件，从而在整个ECMO回路中产生最高的剪切应力。为了测量 DLC 中的血液损伤，通常使用欧拉方法，而不考虑血液暴露于剪切应力的时间或历史。另外，拉格朗日方法最近也被用于通过 DLC 的牛顿血流，从而在非牛顿血流情况下可变剪切率的影响方面留下了研究空白。在本研究中，通过应用拉格朗日方法，使用不同的非牛顿模型研究了 DLC 的血液动力学性能。此外，还跟踪插管内红细胞的运动，以预测其在运动过程中的行为。结果表明，返回腔比 DLC 的其他部分具有更高的压力、速度和剪切应力值。此外，由于来自不同入口的血液混合而观察到再循环，并发现随着血液流速的增加而增加。此外，还发现血液损伤随着流速的增加而增加。在较高流速下，牛顿模型中的血液损伤比其他非牛顿模型中更多。然而，Carreau 模型在较低流速下表现出比其他模型更多的血液损伤。Cross 模型显示 DLC 在将含氧血液输送到三尖瓣出口方面具有更高的功效，因为它在所有其他模型中显示出最少的血液损伤。