Hypochlorite bleach is an easily accessible, commonly used cleaning product. Methamphetamine and ephedrine hydrochloride react rapidly with 3.5 g/L (1:8 dilution of a commercial household bleach) and 21 g/L (2:1 dilution) solutions of sodium hypochlorite bleach in water, with each reaction being complete within 5 min of mixing. The major methamphetamine reaction product was identified as N-chloromethamphetamine which was reliably quantified by dechlorination using a sulfite quench prior to sample extraction and analysis by gas chromatography – mass spectrometry (GC–MS). The initial product from ephedrine was benzaldehyde, and this then formed benzoic acid as a second-generation product in the 3.5 g/L sodium hypochlorite bleach solution.

N-Chloromethamphetamine was observed to persist in solution for several hours with minor formation of benzaldehyde and N-chloro-1-phenylpropan-2-imine, a proposed second-generation product from N-chloromethamphetamine, also detected. Assessment of further N-chloramine reaction products will aid in our ability to estimate exposure risks to those attempting drug remediation using hypochlorite bleach. These observed products can also be used as potential forensic markers of the use of a property for illicit activity if bleach has been used in an attempt to decontaminate the location.

次氯酸盐漂白剂是一种易于使用且常用的清洁产品。甲基苯丙胺和盐酸麻黄碱与 3.5 g/L（市售家用漂白剂 1:8 稀释液）和 21 g/L（2:1 稀释液）次氯酸钠漂白剂水溶液快速反应，每次反应在 5 分钟内完成。混合。主要的甲基苯丙胺反应产物被鉴定为N-氯甲基苯丙胺，在样品提取和气相色谱-质谱 (GC-MS) 分析之前，使用亚硫酸盐淬灭对其进行脱氯，从而对其进行可靠定量。麻黄碱的初始产物是苯甲醛，然后在 3.5 g/L 次氯酸钠漂白溶液中形成苯甲酸作为第二代产物。

观察到N-氯甲基苯丙胺在溶液中持续存在数小时，同时形成少量苯甲醛和 N-氯-1-苯基丙-2-亚胺（ N-氯甲基苯丙胺的第二代产物）也被检测到。对 N-氯胺反应产物的进一步评估将有助于我们评估那些尝试使用次氯酸盐漂白剂进行药物修复的人的暴露风险。如果使用漂白剂试图净化该地点，这些观察到的产品还可以用作利用该财产进行非法活动的潜在法证标记。