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Correlation between Treatment Outcomes and Serum Vitamin D Levels As Well As Infliximab Trough Concentration among Chinese Patients with Crohn’s Disease
Gastroenterology Research and Practice ( IF 2 ) Pub Date : 2023-10-6 , DOI: 10.1155/2023/6675401 Xiaomei Song 1 , Huihui Zhang 2 , Hao Wang 1 , Zhongyue Li 2 , Xiaoqin Zhou 2 , Hong Guo 1
Gastroenterology Research and Practice ( IF 2 ) Pub Date : 2023-10-6 , DOI: 10.1155/2023/6675401 Xiaomei Song 1 , Huihui Zhang 2 , Hao Wang 1 , Zhongyue Li 2 , Xiaoqin Zhou 2 , Hong Guo 1
Affiliation
Background. The relationship between vitamin D (vit-D) levels and the effectiveness of infliximab (IFX) in patients with Crohn’s disease (CD) remains controversial. Objective. To evaluate the interaction between vit-D levels and the response to IFX therapy in patients with CD. Methods. This was a retrospective cohort study. Serum vit-D and IFX trough concentrations (TC) were measured in 84 patients, and statistical analyses were performed. Results. The total vit-D deficiency rate at enrollment, at week 14 and week 38, was 64.3%, 41.67%, and 37.5%, respectively (). CD activity index (CDAI) (120, range, 93–142.75) and simplified endoscopic activity score for CD (SES-CD) (2, range, 0–4) at week 14 were lower than that of enrollment (CDAI, 136.5, range, 101.25–196; SES-CD 13, range, 5–23) (). The biochemical remission (BR), clinical remission (CR), endoscopic remission (ER), and response (ERe) rates of week 38 were 76.1%, 88.5%, 22.4%, and 67.2%, respectively. vit-D levels at enrollment were positively correlated with CDAI at week 38 (). IFX serum TC was related to BR (), CR () at week 14, and ERe () at week 38. Conclusion. Among Chinese patients with CD, vit-D levels prior to IFX therapy are related to CDAI scores, and IFX serum TC is associated with BR, CR, and ERe.
更新日期：2023-10-06
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