Abstract

The reaction of copper(II) and zinc(II) acetates with 3-furancarboxylic (HFur) and 2-thiophenecarboxylic (HTph) acids with subsequent addition of 3,5-dimethylpyrazole (HDmpz) gave mononuclear complexes [M(L)₂(HDmpz)₂] (M = Cu(II), L = Fur^– (I), Tph^– (II); Zn(II), L = Fur^– (III)). The structures of compounds I–III were determined by X-ray diffraction. According to X-ray diffraction data, I and II are isostructural: the central Cu(II) atom occurs in a square planar environment formed by two oxygen atoms of carboxylate anions and HDmpz nitrogen atoms; in III, the Zn atom is in the tetrahedral environment of two furoate anions and HDmpz molecules, thus forming the {MO₂N₂} groups. The complexes are additionally stabilized in the crystal by inter- (I and II) and intramolecular (III) hydrogen bonds. The biological activity of I–III was determined in relation to the non-pathogenic Mycolicibacterium smegmatis.

中文翻译：

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铜(II)和锌(II)与杂环酸阴离子和3,5-二甲基吡唑的络合物：合成、结构和生物学性质

摘要

乙酸铜(II)和乙酸锌(II)与3-呋喃甲酸(HFur)和2-噻吩甲酸(HTph)反应，随后添加3,5-二甲基吡唑(HDmpz)，得到单核配合物[M(L) ₂ ( HDmpz) ₂ ] (M = Cu(II)，L = 毛皮^– ( I )，Tph ^– ( II )；Zn(II)，L = 毛皮^– ( III ))。通过X射线衍射确定了化合物I - III的结构。根据X射线衍射数据，I和II是同构的：中心 Cu(II) 原子出现在由两个羧酸阴离子氧原子和 HDmpz 氮原子形成的方形平面环境中；在III中，Zn原子处于两个糠酸根阴离子和HDmpz分子的四面体环境中，从而形成{MO ₂ N ₂ }基团。该配合物还通过分子间（ I和II）和分子内（III）氢键在晶体中稳定。I – III的生物活性是根据非致病性耻垢分枝杆菌确定的。