Evidence for the biosynthetic pathways of the specialized pro-resolving mediator (SPM) protectin D1 (PD1) and its biochemical further local metabolism were presented during the 8th European Workshop on Lipid Mediators, organized June 29th-July 1st, 2022, in Stockholm, Sweden. Herein, we provide an extended and detailed discussion of these topics. PD1, one of 43 SPMs reported so far, exhibits very potent pro-resolution and anti-inflammatory bioactions. Many research groups worldwide have confirmed these and other interesting bioactions. The protectins constitute, together with the lipoxins, resolvins, and maresins, the four individual SPM families, which have received a great interest in basic biomedical research and drug discovery efforts.

2022 年 6 月 29 日至 7 月 1 日在瑞典斯德哥尔摩举办的第八届欧洲脂质介质研讨会上提出了专门的促分解介质 (SPM) 保护素 D1 (PD1) 的生物合成途径及其生化进一步局部代谢的证据。在这里，我们对这些主题进行了扩展和详细的讨论。PD1 是迄今为止报道的 43 个 SPM 之一，表现出非常有效的促消退和抗炎生物作用。世界各地的许多研究小组已经证实了这些和其他有趣的生物作用。保护素与脂氧素、分解素和 maresins 一起构成了四个单独的 SPM 家族，它们在基础生物医学研究和药物发现工作中引起了极大的兴趣。