Severe mental disorders (SMDs) such as schizophrenia (SCZ), major depressive disorder (MDD) and bipolar disorder (BD) are associated with altered brain function. Neuroimaging studies have illustrated spontaneous activity alterations across SMDs, but no meta-analysis has directly compared resting-state regional cerebral blood flow (rCBF) with one another. We conducted a meta-analysis of PET, SPECT and ASL neuroimaging studies to identify specific alterations of rCBF at rest in SMDs. Included are 20 studies in MDD, and 18 studies in SCZ. Due to the insufficient number of studies in BD, this disorder was left out of the analyses. Compared to controls, the SCZ group displayed reduced rCBF in the triangular part of the left inferior frontal gyrus and in the medial orbital part of the bilateral superior frontal gyrus. After correction, only a small cluster in the right inferior frontal gyrus exhibited reduced rCBF in MDD, compared to controls. Differences were found in these brain regions between SCZ and MDD. SCZ displayed reduced rCBF at rest in regions associated with default-mode, reward processing and language processing. MDD was associated with reduced rCBF in a cluster involved in response inhibition. Our meta-analysis highlights differences in the resting-state rCBF alterations between SCZ and MDD.

精神分裂症 (SCZ)、重度抑郁症 (MDD) 和双相情感障碍 (BD) 等严重精神障碍 (SMD) 与大脑功能改变有关。神经影像学研究已经说明了 SMD 的自发活动变化，但没有一项荟萃分析直接比较静息态局部脑血流量 (rCBF)。我们对 PET、SPECT 和 ASL 神经影像学研究进行了荟萃分析，以确定 SMD 中静息时 rCBF 的具体变化。其中包括 20 项 MDD 研究和 18 项 SCZ 研究。由于 BD 的研究数量不足，这种疾病被排除在分析之外。与对照组相比，SCZ 组左侧额下回三角部分和双侧额上回内侧眼眶部分的 rCBF 减少。校正后，与对照组相比，MDD 患者中只有右额下回的一小部分 rCBF 减少。SCZ 和 MDD 之间的这些大脑区域存在差异。SCZ 在与默认模式、奖励处理和语言处理相关的区域中显示出静止时的 rCBF 减少。MDD 与参与反应抑制的簇中 rCBF 的减少有关。我们的荟萃分析强调了 SCZ 和 MDD 之间静息态 rCBF 变化的差异。