To date, there is insufficient evidence to explain the role of adenosinergic receptors in the reconsolidation of long-term spatial memory. In this work, the role of the adenosinergic receptor family (A1, A2A, A2B, and A3) in this process has been elucidated. It was demonstrated that when infused bilaterally into the hippocampal CA1 region immediately after an early nonreinforced test session performed 24 h posttraining in the Morris water maze task, adenosine can cause anterograde amnesia for recent and late long-term spatial memory. This effect on spatial memory reconsolidation was blocked by A1 or A3 receptor antagonists and mimicked by A1 plus A3 receptor agonists, showing that this effect occurs through A1 and A3 receptors simultaneously. The A3 receptor alone participates only in the reconsolidation of late long-term spatial memory. When the memory to be reconsolidated was delayed (reactivation 5 d posttraining), the amnesic effect of adenosine became transient and did not occur in a test performed 5 d after the reactivation of the mnemonic trace. Finally, it has been shown that the amnesic effect of adenosine on spatial memory reconsolidation depends on the occurrence of protein degradation and that the amnesic effect of inhibition of protein synthesis on spatial memory reconsolidation is dependent on the activation of A3 receptors.

中文翻译：

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腺苷能受体参与雄性大鼠空间长期记忆重建的研究

迄今为止，没有足够的证据来解释腺苷能受体在长期空间记忆重建中的作用。在这项工作中，阐明了腺苷能受体家族（A1、A2A、A2B 和 A3）在此过程中的作用。结果表明，在莫里斯水迷宫任务训练后 24 小时进行早期非强化测试后，立即将腺苷双侧注入海马 CA1 区域，可导致近期和晚期长期空间记忆的顺行性遗忘。这种对空间记忆再巩固的作用被 A1 或 A3 受体拮抗剂阻断，并被 A1 加 A3 受体激动剂模拟，表明这种作用通过 A1 和 A3 受体同时发生。A3 受体单独仅参与晚期长期空间记忆的重新巩固。当需要重新巩固的记忆被延迟时（训练后5天重新激活），腺苷的遗忘作用变得短暂，并且在助记痕迹重新激活5天后进行的测试中没有发生。最后，研究表明，腺苷对空间记忆重新巩固的遗忘作用取决于蛋白质降解的发生，而抑制蛋白质合成对空间记忆重新巩固的遗忘作用取决于A3受体的激活。