Purpose

We investigated the volumetric differences in cortical and subcortical structures between patients with complex febrile seizure (FS) and recurrent simple FS. We aimed to identify the brain morphological patterns of children with complex FS.

Methods

Twenty-five patients with complex FS and age- and sex-matched 25 patients with recurrent simple FS with structural magnetic resonance imaging (MRI) scans were studied. Cortical volumetric analysis was performed using a voxel-based morphometry method with the CAT12 toolbox within SPM12. FSL-FIRST was used to obtain volume measures of subcortical deep grey matter structures (amygdala, caudate nucleus, thalamus, nucleus accumbens, putamen, globus pallidus, and hippocampus). The volumetric asymmetry index (AI) and laterality index (LI) were calculated for each subcortical structure.

Results

Compared with recurrent simple FS, complex FS demonstrated lower volume in the left putamen (p = .003) and right nucleus accumbens (p = .001). Additionally, patients with complex FS presented a higher magnitude of AI of the nucleus accumbens (p < .001) compared with recurrent simple FS.

Conclusions

The findings indicate that volumetric analysis may be a useful marker for the detection of FS-induced changes that reflect microstructural alterations. This study is the first to report on alterations in the putamen and nucleus accumbens in FS.

中文翻译：

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复杂性热性惊厥与复发性单纯性热性惊厥的体积磁共振成像差异

 目的

我们研究了复杂性热性惊厥 (FS) 和复发性单纯性 FS 患者皮质和皮质下结构的体积差异。我们的目的是确定患有复杂 FS 的儿童的大脑形态模式。

 方法

研究人员对 25 名复杂 FS 患者以及年龄和性别匹配的 25 名复发性单纯 FS 患者进行了结构磁共振成像 (MRI) 扫描研究。使用基于体素的形态测量方法和 SPM12 中的 CAT12 工具箱进行皮质体积分析。 FSL-FIRST 用于获取皮质下深部灰质结构（杏仁核、尾状核、丘脑、伏隔核、壳核、苍白球和海马）的体积测量。计算每个皮层下结构的体积不对称指数（AI）和偏侧指数（LI）。

 结果

与复发性简单 FS 相比，复杂 FS 的左侧壳核 (p = .003) 和右侧伏核 (p = .001) 的体积较小。此外，与复发性简单 FS 相比，复杂 FS 患者的伏隔核 AI 值更高 (p < .001)。

 结论

研究结果表明，体积分析可能是检测 FS 引起的反映微观结构变化的变化的有用标记。这项研究首次报告了 FS 中壳核和伏核的改变。